Zlecenie 7147346 - Zapytanie ofertowe 08 11 2019 D - usługa: Langendorff...

el zamówienia Celem zamówienia jest realizacja usługi służącej do realizacji badań w projekcie pt. "Nowa generacja immunoterapii nowotworów oparta o aktywację odpowiedzi immunologicznej pacjentów" Przedmiot zamówienia Langendorff isolated perfused heart assay
• Study model: guinea-pig or rat hearts. Prices should be given separately for both species.
• 6 control preparations per study and 6 test preparations for each assay concentration
• 4 concentrations per test compound
• Include positive control
• Measured parameters:
1) Coronary flow (mL/min)
2) Left ventricular pressure parameters:
• Developed pressure: maximal systolic pressure – minimal diastolic pressure (mmHg),
• Max dP/dt: maximal contraction velocity (mmHg/sec),
• Min dP/dt: maximal relaxation velocity (mmHg/sec),
• Heart rate: calculated from ventricular contractions (beats/min)
3) ECG parameters: PR, QRS, RR and QT interval (ms), QTc intervals
• Final report includes methodology, raw data, graphs (if necessary) and interpretation and should be ready within 4 weeks since experimental phase completion.

Estimated amount of assays: 7 (+/- 50%)

Please provide a quote for a single study (control, positive control and test groups) in guinea pig and in rat hearts.
Contractor should declare the possibility to perform 7 assays (on guinea-pig and/or rat hearts) within 18 months.
Please provide a turnaround time from the study ordering till experimental part completion and from experimental part completion until the final report availability.